aldosterone synthase การใช้

• Aldosterone synthase is a member of the cytochrome P450 superfamily of enzymes.
• Aldosterone synthase normally is not ACTH sensitive, and only activated by angiotensin II.
• When CYP11B1 and CYP11B2 are abnormally fused together, too much aldosterone synthase is produced.
• Aldosterone synthase is a steroid hydroxylase cytochrome P450 oxidase enzyme involved in the generation of aldosterone.
• Aldosterone synthase is found within the zona glomerulosa at the outer edge of the adrenal cortex.
• Corticosterone is converted to aldosterone by aldosterone synthase, found only in the mitochondria of glomerulosa cells.
• In the potential case where aldosterone synthase is not metabolically active the body accumulates 11-deoxycorticosterone.
• The CYP11B2 gene provides instructions for making another enzyme called aldosterone synthase, which helps produce aldosterone.
• Inhibition of aldosterone synthase is currently being investigated as a medical treatment for hypertension, heart failure, and renal disorders.
• This layer is the main site for production of aldosterone, a mineralocorticoid, by the action of the enzyme aldosterone synthase.
• The product of this hybrid gene is aldosterone synthase that is ACTH-sensitive in the zona fasciculata of the adrenal gland.
• The last part is mediated either by the aldosterone synthase ( for aldosterone ) or by the 11?-hydroxylase ( for corticosterone ).
• The last parts are mediated either by the aldosterone synthase ( for aldosterone ) or by the 11?-hydroxylase ( for corticosterone ).
• The last part is either mediated by the aldosterone synthase ( for aldosterone ) or by the 11?-hydroxylase ( for corticosterone ).
• Although in normal subjects, ACTH accelerates the first step of aldosterone synthesis, ACTH normally has no effect on the activity of aldosterone synthase.
• The in-active proteins are caused by the autosomal recessive inheritance of defective CYP11B2 genes in which genetic mutations destroy the enzymatic activity of aldosterone synthase.
• These enzymes are nearly identical ( they share 11?-hydroxylation and 18-hydroxylation functions ), but aldosterone synthase is also able to perform an 18-oxidation.
• However, in subjects with glucocorticoid-remediable aldosteronism, ACTH increases the activity of existing aldosterone synthase, resulting in an abnormally high rate of aldosterone synthesis and hyperaldosteronism.
• Moreover, aldosterone synthase is found within the zona glomerulosa at the outer edge of the adrenal cortex; 11?-hydroxylase is found in the zona fasciculata and zona glomerulosa.
• Moreover, aldosterone synthase is found within the zona glomerulosa at the outer edge of the adrenal cortex; 11?-hydroxylase is found in the zona glomerulosa and zona fasciculata.